Table 2.
Genes displaying altered expression in MeCP2-deficient systems that encode mitochondrial structural and organization factors.
| Gene | Coding genome | Protein function | Δ | Cell/ tissue type | Organism | References |
|---|---|---|---|---|---|---|
| HMN | mtDNA | 16sRNA | ↑ | Brain tissue | Human (RTT patients) | Gibson et al., 2010 |
|
TIMM 8B, 9, 10, 13, 17A TOMM7 TSPO |
nDNA | Mitochondrial import and localization | ↑ | Lympho-monocytes | Human (RTT patients) | Pecorelli et al., 2013 |
|
MRPL13, 20, 21, 33, 51, 52 MRPS25, 30, 33, 36 |
nDNA | Mitochondrial ribosomal proteins | ↑ | Lympho-monocytes | Human (RTT patients) | Pecorelli et al., 2013 |
| ESC-derived neurons1 | Human (RTT patients) | Tanaka et al., 2013 | ||||
| Pgc-1α | nDNA | Mitochondrial biogenesis | ↓ | Skeletal muscles | MeCP2-null mice | Gold et al., 2014 |
| Crls1 | nDNA | Synthesis of cardiolipin | ↓ | Skeletal muscles | MeCP2-null mice | Gold et al., 2014 |
| NR3C1 | nDNA | Mitochondrial transcription factor | ↑ | ESC-derived neurons | Human (RTT patients) | Tanaka et al., 2013 |