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. 2017 Mar 14;8:128. doi: 10.3389/fphys.2017.00128

Figure 6.

Figure 6

IAPs involvement in fibroblast resistance to apoptosis. (A) Representative WB using specific Abs for different IAPs protein expression in the mouse lung cells–ECs, EpCs, wt-, Cav1−/− and Cav2−/− fibroblasts, as indicated; n = 6 for each IAP. (B) The time course and transient nature of siRNA-mediated knockdown of four BIRCs: NAIP, cIAP1, cIAP-2, and XIAP- in Cav-null fibroblasts; n = 4 for each IAP and Cav-null fibroblasts. The effects of individual knockdown as indicated–XIAP (C), cIAP1 (D) and cIAP2 (E), n = 4 experiments for every type of fibroblasts and every time point, *p < 0.05 between controls and cav –null fibroblasts but †p < 0.1 in between Cav1−/− and Cav2−/− fibroblasts. The combined knockdown–XIAP/cIAP1 (F), cIAP1/cIAP2 (G), and XIAP/cIAP1 (H) effects in fibroblasts resistance to FasL-induced apoptosis; n = 6, *p < 0.05 when compared to untreated fibroblasts.