Table 1.
The onset of morphological apoptotic alterations of mouse lung fibroblasts induced by FasL + CHM.
| Morphology | Wt-fibroblasts | Cav1−/− fibroblasts | Cav 2−/− fibroblasts | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 h | 2 h | 6 h | 24 h | 1 h | 2 h | 6 h | 24 h | 1 h | 2 h | 6 h | 24 h | |
| CELL SURFACE | ||||||||||||
| Shrinkage | +++ | +++ | +++ | |||||||||
| Retraction | +++ | +++ | +++ | |||||||||
| Filopodia | ++ | + | + | ++ | + | + | ++ | +++ | ± | + | ++ | +++ |
| Blebbing | ± | + | ++ | +++ | + | + | ++ | ± | + | + | ++ | |
| CYTOPLASM | ||||||||||||
| Myelinoid bodies | + | + | ++ | ± | + | + | + | ± | + | ++ | + | + |
| Enlarged ER | + | ++ | ++ | + | + | +++ | + | ++ | ++ | |||
| NUCLEUS | ||||||||||||
| Condensation | + | ++ | +++ | ± | + | ++ | ± | + | +++ | |||
+, <40% of cells; ++, <50% of cells; +++, >60%; ±, inconsistent presence.