Table 1.
Expression of heat shock, molecular chaperone, LPS O-antigen biosynthesis, and LPS phosphorylation genes in response to Tobramycin and host cells.
| Gene ID | Name | Description | Sample Name | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| P0.3 | P2 | APD0 | APD0.3 | |||||||
| Components | ||||||||||
| PAO1 | PAO1 | PAO1 | PAO1 | |||||||
| 0.3 μg/ml Tobramycin | 2 μg/ml Tobramycin | No Tobramycin A549 and dHL60 | 0.3 μg/ml Tobramycin A549 and dHL60 | |||||||
| Tobramycin response | Fold change* | P-value | Fold change* | P-value | Fold change* | P-value | Fold change* | P-value | ||
| PA3126 | ibpA | heat shock protein IbpA | 0.94 | 6.40E-01 | 1.44 | 9.69E-03 | 0.81 | 9.80E-01 | 2.05 | 6.42E-14 |
| PA4385 | groEL | molecular chaperone GroEL | 1.12 | 2.70E-01 | 2.12 | 1.78E-19 | 1.43 | 5.27E-10 | 4.11 | 3.33E-122 |
| PA4386 | groES | co-chaperonin GroES | 1.20 | 6.82E-02 | 2.55 | 6.71E-30 | 1.40 | 1.05E-08 | 3.88 | 1.48E-103 |
| PA4760 | dnaJ | molecular chaperone DnaJ | 1.21 | 4.61E-01 | 2.49 | 1.77E-05 | 3.89 | 8.0380E-17 | 8.22 | 1.01E-50 |
| PA4761 | dnaK | molecular chaperone DnaK | 1.12 | 4.35E-01 | 2.19 | 3.31E-11 | 1.16 | 9.73E-03 | 4.13 | 4.79E-61 |
| PA4762 | grpE | heat shock protein GrpE | 1.33 | 2.22E-01 | 3.19 | 8.51E-10 | 2.32 | 2.2053E-07 | 6.93 | 7.25E-45 |
| PA5053 | hslV | ATP-dependent protease peptidase subunit | 1.04 | 9.25E-01 | 2.71 | 8.79E-05 | 5.16 | 5.07E-18 | 11.90 | 6.68E-55 |
| PA5054 | hslU | ATP-dependent protease ATP-binding subunit HslU | 1.18 | 6.38E-01 | 2.95 | 9.95E-05 | 4.95 | 6.92E-14 | 11.30 | 1.22E-41 |
| LPS O-ANTIGEN BIOSYNTHESIS | ||||||||||
| PA3149 | wbpH | glycosyltransferase WbpH | 0.56 | 1.48E-02 | 0.16 | 2.37E-08 | 2.81 | 1.00E-14 | 2.98 | 8.4451E-17 |
| PA3150 | wbpG | LPS biosynthesis protein WbpG | 0.91 | 5.38E-01 | 0.15 | 2.46E-15 | 3.02 | 2.56E-30 | 2.84 | 9.6281E-28 |
| PA3153 | Wzx | O-antigen translocase | 0.96 | 8.49E-01 | 0.01 | 7.79E-09 | 2.13 | 5.49E-06 | 2.18 | 1.76E-06 |
| PA3154 | Wzy | B-band O-antigen polymerase | 1.24 | 4.39E-01 | 0.12 | 1.89E-05 | 3.89 | 4.96E-14 | 4.51 | 5.1553E-18 |
| LPS PHOSPHORYLATION | ||||||||||
| PA5006 | hypothetical protein | 0.90 | 6.65E-01 | 1.01 | 9.93E-01 | 4.34 | 3.3053E-24 | 4.79 | 7.7100E-29 | |
| PA5007 | wapG | hypothetical protein | 0.95 | 8.34E-01 | 0.81 | 4.72E-01 | 4.01 | 2.0919E-15 | 5.14 | 6.2265E-23 |
| PA5008 | wapP | hypothetical protein | 1.08 | 7.17E-01 | 0.83 | 3.52E-01 | 1.69 | 3.22E-05 | 2.08 | 9.1969E-09 |
| PA5009 | waaP | lipopolysaccharide kinase WaaP | 1.15 | 7.29E-01 | 0.76 | 5.12E-01 | 7.02 | 1.5556E-18 | 5.98 | 3.2275E-15 |