Table 1.

Role of type I interferons (IFN) and type III IFN during enteric viral infections.

	Role of type I IFN	Type III IFN
Rotavirus	Type I IFN protect from systemic infection and heterologous oral infection (49, 50)	Type III IFN protect from oral homologous infection by restriction of replication within intestinal epithelial cells (IECs) (12, 29)
Norovirus	Type I IFN protect from systemic spread of acute norovirus infection (48, 51)	Type III IFN protect from persistent norovirus infection; treatment with IFN-λ clears persistent infection (15)
Reovirus	Type I IFN restricts reovirus replication in lamina propria leukocyte (14)	Type III IFN restricts reovirus replication in IECs and fecal shedding (14)
EMCV	IFN-α treatment reduces titer in hearts during systemic infection (47)	Type III IFN does not protect during systemic infection (47); type III IFN protects from oral infection (52)