Figure 2.

The metabolic features of epithelial-to-mesenchymal transition (EMT). Several components of the molecular pathways driving EMT have a clear impact on cell metabolism and vice versa, resulting in a metabolic rewiring which sustains the EMT transcriptional program. EMT-committed cancer cells could rely on an aerobic glycolytic metabolism or could shift toward the more efficient oxidative phosphorylation (OXPHOS), dependent on tumor type and/or tumor stage. Here, we have highlighted in red circles/ellipses EMT transcriptional factors that are affected by the metabolites reported in different tumor types.