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. 2016 Dec 16;13(2):461–466. doi: 10.3892/etm.2016.3979

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Intrathecal injection of anti-MCP-1 neutralizing antibody attenuated mechanical allodynia in MTBP rats. (A) PWL and (B) TWL values were measured between days 1–18 after cell inoculation. Morphine was intrathecally injected between days 9 and 18 in all BM groups. A single intrathecal administration of anti-MCP-1 antibody (in groups BM+Ab and B+Ab), or control IgG (10 µg; in groups BM+IgG and B+IgG) was performed on day 15 after inoculation of Walker 256 cells. Values are presented as the mean ± standard error (n=8 rats in each group). ‘//’ in the x-axis indicates the time at which morphine administration was initiated. *P<0.05 vs. BM and BM+IgG groups. PWT, paw withdrawal threshold; TWL, thermal withdrawal latency; B, bone cancer pain group; BM, morphine tolerance and bone cancer pain group.