Table II.
Physical and biochemical parameters after 24 weeks of study in control, DN and DN+L-NAME group mice.
| Parameters | Control | DN | DN + L-NAME |
|---|---|---|---|
| Number | 10 | 9a | 10 |
| Body weight (g) | 22.09±2.05 | 41.93±1.32 | 47.97±0.87 |
| Kidney/body weight ratio (%) | 0.45±0.12 | 0.39±0.28 | 0.31±0.31 |
| Glucose (mmol/l) | 6.72±0.01 | 23.80±0.01 | 14.41±0.009 |
| HbA1c (%) | 5.3±0.09 | 9.8±0.34 | 7.6±0.12 |
| HbA1c (mmol/mol) | 34.426±0.98 | 83.607±3.76 | 59.563±1.31 |
| Total cholesterol (mmol/l) | 4.9±0.17 | 11.8±1.01 | 9.4±0.97 |
| Triglycerides (mmol/l) | 1.5±0.24 | 3.7±0.33 | 2.6±0.42 |
| HDL (mmol/l) | 1.3±0.32 | 2.7±0.11 | 1.7±0.21 |
| LDL (mmol/l) | 4.5±0.56 | 10.3±0.31 | 7.4±0.11 |
Data are presented as the mean ± standard deviation.
a
One mouse from this group succumbed at the 22nd week. DN, diabetic nephropathy; L-NAME, NG-nitro-L-Arginine methylester; HbA1c, glycated hemoglobin; HDL, high density lipoprotein; LDL, low density lipoprotein.