Table 5.
Diagnostic performances of combined methods to detect malignancy at specific cut-off values
| Developed method | Sensitivity % |
95% CI | Specificity % |
95% CI | PPV % |
95% CI | NPV % |
95% CI | Accuracy % |
|---|---|---|---|---|---|---|---|---|---|
| RMI > 200 and VFI > 0.31 | 51.6 | 33.1–69.9 | 95.5 | 87.3–99.1 | 84.2 | 60.4–96.6 | 80.8 | 70.3–88.8 | 81.4 |
| Simple rules with expert opiniona and VFI > 0.31 | 71.0 | 52.0–85.8 | 95.5 | 87.3–99.1 | 88.0 | 68.8–97.5 | 87.5 | 77.6–94.1 | 86.7 |
| LR2 > 25 and VFI > 0.31 | 64.5 | 45.4–80.8 | 97.0 | 89.5–99.6 | 90.9 | 70.8–98.9 | 85.3 | 75.3–92.4 | 86.5 |
IOTA International Ovarian Tumor Analysis; CI Confidential interval; PPV Positive predictive value; NPV Negative predictive value; RMI Risk of malignancy index; VFI Vascularization flow index; LR2 Logistic regression model 2
aTwo step-strategy: As a result of inconclusive by simple rules, the expert evaluates the tumor