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. 2017 Mar 14;16:61. doi: 10.1186/s12943-017-0627-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Overexpression of GPR87 correlates with pancreatic carcinoma progression and poor prognosis. a. Expression profile of GPR87 mRNA in primary pancreatic cancer tissues (n = 178) and normal pancreatic tissues (n = 4; p < 0.01; TCGA) (left panel); expression profile of GPR87 mRNA in primary pancreatic cancer tissues (n = 36) and normal pancreatic tissues (n = 16; p < 0.01; GSE16515) (right panel). b. Kaplan-Meier survival curves comparing pancreatic cancer patients with low and high GPR87 expression levels (n = 115; p < 0.027; TCGA). Higher and lower expression was based on median value of GPR87 mRNA. c. Western blot analysis of GPR87 expression in human pancreatic ductal epithelial cells (HPDECs) and six pancreatic cancer cell lines. d. Expression of GPR87, as determined by Western blot, in eight paired primary pancreatic cancer tissues (T) and the matched adjacent non-tumor tissues (ANT) from the same patient. α-tubulin served as a loading control. e. IHC staining indicating GPR87 protein expression in human primary pancreatic cancer compared with adjacent pancreatic tissues. f. Kaplan–Meier analysis of overall survival stratified by low GPR87 expression (n = 47) and high GPR87 expression (n = 49). GPR87 upregulation was significantly correlated with shorter overall survival (p = 0.040)