Table 1.
Baseline Characteristics Stratefied by Hcy quartiles
| Hcy (μmol/L) | Total | Q1 | Q2 | Q3 | Q4 | P-value | P for trend |
|---|---|---|---|---|---|---|---|
| Median (Min-Max) | 11.98 (4.66–141.47) | 8.83 (4.66–9.99) | 11.02 (10.00–11.97) | 13.23 (11.98–14.92) | 18.50 (14.93–141.47) | ||
| N | 4660 | 1161 | 1169 | 1161 | 1169 | ||
| Age (year-old), mean ± SD | 56.75 ± 8.91 | 53.31 ± 7.41 | 56.28 ± 7.97 | 58.59 ± 9.21 | 58.82 ± 9.72 | <0.001 | <0.001 |
| Sex, N (%) | |||||||
| Male | 1778 (38.15%) | 117 (10.08%) | 319 (27.29%) | 533 (45.91%) | 809 (69.20%) | <0.001 | <0.001 |
| Female | 2882 (61.85%) | 1044 (89.92%) | 850 (72.71%) | 628 (54.09%) | 360 (30.80%) | ||
| Scr (μmol/L), mean ± SD | 59.44 ± 14.23 | 57.22 ± 9.05 | 63.25 ± 11.66 | 69.08 ± 13.44 | 77.34 ± 17.78 | <0.001 | <0.001 |
| TC (mmol/L), mean ± SD | 5.34 ± 0.98 | 5.37 ± 0.99 | 5.40 ± 0.91 | 5.35 ± 0.97 | 5.23 ± 1.03 | <0.001 | <0.001 |
| TG (mmol/L), Median (IQR) | 1.28 (0.91–1.85) | 1.24 (0.88–1.84) | 1.25 (0.90–1.73) | 1.28 (0.94–1.81) | 1.35 (0.95–2.01) | <0.001 | <0.001 |
| HDL-C (mmol/L), mean ± SD | 1.43 ± 0.38 | 1.49 ± 0.36 | 1.47 ± 0.36 | 1.43 ± 0.38 | 1.36 ± 0.39 | <0.001 | <0.001 |
| LDL-C (mmol/L), mean ± SD | 3.27 ± 0.81 | 3.28 ± 0.81 | 3.32 ± 0.77 | 3.30 ± 0.81 | 3.19 ± 0.85 | <0.001 | 0.011 |
| FBG (mmol/L), mean ± SD | 6.16 ± 1.80 | 6.12 ± 1.80 | 6.20 ± 1.91 | 6.20 ± 1.85 | 6.10 ± 1.62 | 0.389 | 0.728 |
| BMI (Kg/m2), mean ± SD | 26.00 ± 3.37 | 25.86 ± 3.54 | 25.92 ± 3.31 | 26.07 ± 3.36 | 26.1 ± 3.28 | 0.130 | 0.019 |
| SBP (mmHg), mean ± SD | 133.89 ± 16.85 | 130.91 ± 16.34 | 132.90 ± 16.49 | 135.07 ± 16.91 | 136.65 ± 17.12 | <0.001 | <0.001 |
| DBP (mmHg), mean ± SD | 75.21 ± 9.95 | 74.48 ± 9.48 | 75.07 ± 9.85 | 74.85 ± 9.86 | 76.42 ± 10.47 | <0.001 | <0.001 |
| Pulse (bpm), mean ± SD | 78.51 ± 11.41 | 78.15 ± 10.36 | 78.25 ± 11.20 | 78.50 ± 11.61 | 79.13 ± 12.35 | 0.159 | 0.033 |
| Education level, N (%) | |||||||
| Elementary above | 4581 (98.30%) | 1150 (99.05%) | 1153 (98.63%) | 1137 (97.93%) | 1141 (97.60%) | 0.029 | 0.003 |
| Illiterate | 79 (1.70%) | 11 (0.95%) | 16 (1.37%) | 24 (2.07%) | 28 (2.40%) | ||
| Smoking status, N (%) | |||||||
| Current and former | 1249 (26.80%) | 96 (8.27%) | 230 (19.67%) | 356 (30.66%) | 567 (48.50%) | <0.001 | <0.001 |
| Never | 3411 (73.20%) | 1065 (91.73%) | 939 (80.33%) | 805 (69.34%) | 602 (51.50%) | ||
| Alcohol drinking, N (%) | |||||||
| Current and former | 1204 (25.84%) | 136 (11.71%) | 242 (20.70%) | 319 (27.48%) | 507 (43.37%) | <0.001 | <0.001 |
| Never | 3456 (74.16%) | 1025 (88.29%) | 927 (79.30%) | 842 (72.52%) | 662 (56.63%) | ||
| Physical activity, N (%) | |||||||
| Once a week above | 3737 (80.43%) | 896 (77.24%) | 928 (79.66%) | 971 (83.85%) | 942 (80.79%) | <0.001 | 0.005 |
| Others | 912 (19.57%) | 264 (22.76%) | 237 (20.34%) | 187 (16.15%) | 224 (19.21%) | ||
| Vitamin B supplement, N (%) | |||||||
| Once a week above | 386 (8.28%) | 137 (11.80%) | 105 (9.01%) | 77 (6.64%) | 67 (5.74%) | <0.001 | <0.001 |
| Others | 4269 (91.72%) | 1024 (88.20%) | 1061 (90.99%) | 1083 (93.36%) | 1101 (94.26%) | ||
Abbreviations: TC Total cholesterol, TG Triglycerides, HDL-C High density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol, Hcy Homocysteine, Scr Serum creatinine, BMI Body mass index, FBG Fasting blood glucose, SBP Systolic blood pressure, DBP Diastolic blood pressure, IQR Interquartile range