Table 1.

Data sets used in the discovery and direct validation of the bacterial/viral metascore.

Accession	Author	Tissue	Platform	Demographic	Bacteria	Viruses	Number healthy	Number bacterial	Number viral
A. Discovery data sets
GSE6269	Ramilo	PBMC	GPL2507	Children admitted with infection	Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae	Influenza	0	16	8
			GPL570		S. aureus, S. pneumoniae	Influenza	0	12	10
			GPL96		S. aureus, S. pneumoniae	Influenza	6	73	18
GSE20346	Parnell	Whole blood	GPL6947	Adults with CAP	Unknown bacterial pneumonia	Influenza	36	12	8
GSE40012	Parnell	Whole blood	GPL6947	Adults with CAP	Unknown bacterial pneumonia	Influenza	18	36	11
GSE40396	Hu	Whole blood	GPL10558	Febrile children in emergency department	Multiple	Adenovirus, enterovirus, rhinovirus, HHV6	22	8	35
GSE42026	Herbeg	Whole blood	GPL6947	Children admitted with infection	Streptococcus and Staphylococcus spp.	Influenza, RSV	33	18	41
GSE66099	Wong	Whole blood	GPL570	Septic children in PICU	Multiple	Influenza, HSV, CMV, BK, adenovirus	47	109	11
B. Validation data sets
GSE15297	Popper	Whole blood	GPL8328	Febrile children	Scarlet fever (Streptococcus)	Adenovirus	0	5	8
GSE25504	Smith	Whole blood	GPL13667	Septic neonates	Multiple	Rhinovirus, CMV	6	11	3
			GPL6947		Multiple	CMV	35	26	1
GSE60244	Suarez	Whole blood	GPL10558	Adults hospitalized with LRTI	Gram-positive and atypical	Influenza, RSV, MPV	40	22	71
GSE63990	Tsalik	Whole blood	GPL571	Adults with ARI	Multiple	Multiple	0	70	115
E-MEXP-3589	Almansa	Whole blood	GPL10332	Adults with COPD with infection	Gram-positive, Gram-negative, atypical	Influenza, RSV, MPV	4	4	5

CAP, community-acquired pneumonia; HHV6, human herpesvirus 6; RSV, respiratory syncytial virus; HSV, herpes simplex virus; CMV, cytomegalovirus; MPV, metapneumovirus; PICU, pediatric intensive care unit; LRTI, lower respiratory tract infection; ARI, acute respiratory infection; COPD, chronic obstructive pulmonary disease.