Table 1.
Cell cycle phenotypes of loss-of-function mutants in essential genes encoding protein synthesis and ribosome biogenesis factors in S. cerevisiae.
| Systematic name | Standard name/ alias | Function | Cell cycle phenotype | Ref. |
| Translation Initiation Factors | ||||
| YER165W | PAB1 | Poly(A) binding protein | G1 | 136 |
| YJR007W | SUI2 | eIF2α | G1 | 52 |
| YKR059W | TIF1 | eIF4A | G1 | 52 |
| YLR291C | GCD7 | eIF2Bβ | G1 | 52 |
| YMR146C | TIF34 | eIF3i | G1 | 52 |
| YNL244C | SUI1/MOF2 | eIF1 | G1 | 52 |
| YOL139C | CDC33/TIF45 | eIF4E | G1 | 45,46 |
| YOR361C | PRT1/CDC63 | eIF3b | G1 | 47,48 |
| Translation Elongation Factors | ||||
| YLR249W | YEF3 | eEF1Bγ | G2/M, other | 52 |
| tRNA synthetases | ||||
| YGR264C | MES1 | MetRS | G1 | 51 |
| YLL018C | DPS1 | AspRS | G1 | 52 |
| YOR335C | ALA1/CDC64 | AlaRS | G1 | 50 |
| YPL160W | CDC60 | LeuRS | G1 | 50 |
| tRNA | ||||
| tQ(CUG)M | CDC65 | tRNA-Gln | G1 | 137 |
| Ribosome biogenesis and assembly | ||||
| YBL004W | UTP20 | 18S rRNA biogenesis | other | 52 |
| YBR142W | MAK5 | 60S ribosome subunit biogenesis | G1 | 52 |
| YCL054W | SPB1 | AdoMet-dependent methyltransferase | G1 | 52 |
| YCR057C | PWP2/UTP1 | 18S rRNA biogenesis | G1 | 108,138 |
| YDL031W | DBP10 | 40S biogenesis and 35S pre-rRNA processing | G1 | 52 |
| YDL060W | TSR1 | 20S pre-rRNA processing | G1 | 52 |
| YDL148C | NOP14/UTP2 | 18S rRNA biogenesis | G1 | 138 |
| YDL153C | SAS10/UTP3 | 18S rRNA biogenesis | G1, other | 52,138 |
| YDL166C | FAP7 | 20S pre-rRNA processing | G1 | 52 |
| YDR060W | MAK21 | 60S ribosome subunit biogenesis | G1 | 52 |
| YDR091C | RLI1 | Ribosome biogenesis | G1 | 52 |
| YDR324C | UTP4 | 18S rRNA biogenesis | G1 | 138 |
| YDR398W | UTP5 | 18S rRNA biogenesis | G1 | 52,138 |
| YDR449C | UTP6 | 18S rRNA biogenesis | G1 | 138 |
| YER006W | NUG1 | Export of 60S ribosomal subunits from the nucleus | G1 | 52 |
| YER082C | UTP7 | 18S rRNA biogenesis | G1 | 52,138 |
| YER127W | LCP5 | 18S rRNA maturation | G1 | 52 |
| YFL002C | SPB4 | 60S ribosome biogenesis | G1 | 52 |
| YGR090W | UTP22 | 18S rRNA biogenesis | G1 | 52 |
| YGR103W | NOP7 | 60S ribosome subunit biogenesis | G1 | 52 |
| YGR128C | UTP8 | 18S rRNA biogenesis | G1 | 52,138 |
| YGR245C | SDA1 | 60S ribosome biogenesis and actin organization | G1 | 52 |
| YHR072W-A | NOP10 | 18S rRNA maturation | G2/M | 52 |
| YHR085W | IPI1 | 35S pre-rRNA processing | G1 | 52 |
| YHR088W | RPF1 | Export of 60S ribosomal subunits from the nucleus | G1 | 52 |
| YHR089C | GAR1 | Modification and cleavage of the 18S pre-rRNA | other | 52 |
| YHR143W-A | RPC10 | RNA polymerase subunit common to RNA polymerases I, II, and III | G2/M | 52 |
| YHR196W | UTP9 | 18S rRNA biogenesis | G1 | 52,138 |
| YJL033W | HCA4 | 18S rRNA biogenesis | G1 | 52 |
| YJL069C | UTP18 | 18S rRNA biogenesis | G1 | 52 |
| YJL109C | UTP10 | 18S rRNA biogenesis | G1 | 138 |
| YJR002W | MPP10 | 18S rRNA biogenesis | G1, other | 52 |
| YKL009W | MRT4 | Ribosome assembly | G1 | 52 |
| YKL099C | UTP11 | 18S rRNA biogenesis | G1 | 52,138 |
| YKL172W | EBP2 | 25S rRNA maturation | G1 | 52 |
| YLL008W | DRS1 | DEAD-box protein, 60S ribosomal subunits | G1 | 52 |
| YLR002C | NOC3 | 60S ribosome subunit biogenesis | G2/M | 52 |
| YLR009W | RLP24 | 60S ribosome subunit biogenesis | G1 | 52 |
| YLR129W | DIP2 | 18S rRNA biogenesis | G1 | 52,138 |
| YLR167W | RPS31 | Ribosomal protein | G1, other | 52 |
| YLR175W | CBF5 | Pseudouridine synthase | other | 52 |
| YLR186W | EMG1 | Methyltransferase for rRNA | G1 | 52 |
| YLR222C | UTP13 | 18S rRNA biogenesis | G1 | 138 |
| YLR276C | DPB9 | DEAD-box helicase, 27S rRNA processing | G1 | 52 |
| YML093W | UTP14 | 18S rRNA biogenesis | G1 | 52,138 |
| YMR093W | UTP15 | 18S rRNA biogenesis | G1 | 138 |
| YMR128W | ECM16 | DEAD-box helicase, 18S rRNA synthesis | G1 | 52 |
| YMR290C | HAS1 | Helicase, biogenesis of 40S and 60S ribosome subunits | G1 | 52 |
| YNL113W | RPC19 | RNA polymerase subunit common to RNA polymerases I and III | G1 | 52 |
| YNL124W | NAF1 | pre-rRNA processing | G1 | 52 |
| YNL163C | RIA1 | 80S ribosome assembly | G1 | 52 |
| YNL207W | RIO2 | 40S ribosome subunit biogenesis | G1 | 52 |
| YNR038w | DPB6 | DEAD-box helicase | G1 | 52 |
| YNR053C | NOG2 | 60S ribosome subunit biogenesis | G1 | 52 |
| YOL010W | RCL1 | 18S rRNA maturation | G2/M, other | 52 |
| YOR078W | BUD21/UTP16 | 18S rRNA biogenesis | G1 | 138 |
| YOR119C | RIO1 | 40S ribosome subunit biogenesis | other | 52 |
| YOR210W | RPB10 | RNA polymerase subunit common to RNA polymerases I, II, and III | G1 | 52 |
| YOR224C | RPB8 | RNA polymerase subunit common to RNA polymerases I, II, and III | G1 | 52 |
| YOR294W | RRS1 | Export of 60S ribosomal subunits from the nucleus | G1, other | 52 |
| YOR340C | RPA43 | RNA polymerase I subunit | G1 | 52 |
| YOR341W | RPA190 | RNA polymerase I subunit | G1 | 52 |
| YPL012W | RRP12 | Export of ribosomal subunits from the nucleus | G1 | 52 |
| YPL043W | NOP4 | 27S rRNA processing, 60S ribosome subunit biogenesis | G1, other | 52 |
| YPL093W | NOG1 | 60S ribosome subunit biogenesis | G1 | 52 |
| YPL126W | NAN1 | 18S rRNA biogenesis | G1 | 52,138 |
| YPL211W | NIP7 | 60S ribosome subunit biogenesis | G1, other | 52 |
| YPL217C | BMS1 | 40S synthesis and 35S pre-rRNA processing | G1 | 52 |
| YPL266W | DIM1 | 18S rRNA dimethylase | G1 | 52 |
| YPR016C | TIF6/CDC95 | eIF6 | G1 | 52 |
| YPR110C | RPC40 | RNA polymerase subunit common to RNA polymerases I and III | G1 | 52 |
| YPR144C | UTP19 | Maturation and nuclear export of 40S ribosomal subunits | G1 | 52 |