Figure 2. FIGURE 2: Phylogenetic tree iron-zinc permeases.

ZIPCO and ZIP1 are two zinc-iron permeases, the first is important for mosquito-to-mouse transition, while the second is vital for male gametocyte formation and transmission to the malaria mosquito. This is a maximum likelihood tree of the orthologues found in a variety of eukaryotes, including humans. Nodes with support values <50 are left unresolved. The aconoidasidan paralogues ZIPCO and ZIP1 resolve with good support values, suggesting that the genes duplicated after differentiation of the Aconoidasida.