Figure 1.

Macroscopic aspects of the effect of a nanostructured 8.5% Doxycycline (DOX) locally applied gel (Dental gel^®) on alveolar bone loss. Experimental periodontal disease was also induced in the animals from the Non-Treated (NT) and in vehicle (V) groups. Naïve group was not submitted to EPD and received no treatment. Bars represent the mean ± Standard Error of Mean (SEM) of alveolar bone loss (mm; N=6). Asterisk indicates a statistically significant difference between the DOX group and NT group (*P<0.05; Bonferroni, ANOVA)