TABLE 2.
Transgenic and Knockout Studies of Superoxide Dismutases and Glutathione Peroxidase
| Study | Insult | Findings | Reference |
|---|---|---|---|
| SOD1 +/− | Permanent MCAO | Decreased cortical infarct (−35%) | Kinouchi et al.63 |
| SOD1 +/− | Permanent MCAO | No protection | Chan et al.90 |
| SOD1 +/− | Transient MCAO | Decreased infarct | Yang et al.91 |
| SOD1 +/− | Transient MCAO | Sustained hsp70 mRNA expression | Kamii et al.92 |
| SOD1 +/− | Transient MCAO | Sustained c-fos mRNA expression | Kamii et al.93 |
| SOD1 +/− | Global ischemia | Induction of hsp70 | Kondo et al.94 |
| SOD1 +/− | Transient MCAO | Decreased injury (−50%) | Kamii et al.95 |
| SOD1 +/− | Neonatal hypoxia | Increased injury in neonates | Ditelberg et al.96 |
| SOD1 +/− | Neonatal hypoxia | Increased injury in neonates | Fullerton et al.97 |
| SOD1 +/− | Global ischemia | Decreased injury (−50%) | Chan et al.64 |
| SOD1 +/− | Global ischemia | Decreased injury (−50%) | Murakami et al.69 |
| SOD1 +/− | Transient MCAO | Decreased DNA fragmentation | Fujimura et al.98 |
| SOD1 +/− | Transient MCAO | Decreased cytochrome c release | Fujimura et al.7 |
| SOD1 +/− | Transient MCAO | Down-regulation of nuclear factor-κB | Huang et al.99 |
| SOD1 +/− | Transient MCAO | Decreased activation of activator protein-1 | Huang et al.100 |
| SOD1 +/− | Global ischemia | Decreased active caspase-3, -9 | Sugawara et al.10 |
| SOD1 +/− | Transient MCAO | Decreased ERK activation | Noshita et al.8 |
| SOD1 +/− | Transient MCAO | Decreased Bad activation | Saito et al.11 |
| SOD1 −/− | Transient MCAO | Increased infarct (+40%) | Kondo et al.67 |
| SOD1 −/− | Transient MCAO | Increased lesion size and edema | Kondo et al.68 |
| SOD1 −/− | Global ischemia | Increased cell death | Kawase et al.66 |
| SOD1 +/−, −/− | Permanent MCAO | No increase in infarct volume | Fujimura et al.101 |
| SOD2 +/− | Transient MCAO | Decreased injury | Keller et al.71 |
| SOD2 −/+ | Permanent MCAO | Increased infarct (+66%) | Murakami et al.69 |
| SOD2 −/+ | Permanent MCAO | Increased active caspase-9 | Fujimura et al.70 |
| SOD2 −/+ | Transient MCAO | Increased cytochrome c release | Noshita et al.102 |
| SOD2 −/+ | Permanent MCAO | Increased superoxide production | Kim et al.103 |
| ECSOD +/− | Transient MCAO | Decreased infarct (−28%) | Sheng et al.72 |
| ECSOD +/+ | Global ischemia | Decreased injury (−48%) | Sheng et al.74 |
| ECSOD −/− | Transient MCAO | Increased infarct (+81%) | Sheng et al.73 |
| GSHPx-1 +/+ | Transient MCAO | Decreased infarct | Weisbrot et al.76 |
| GSHPx-1 −/− | Transient MCAO | Increased apoptosis | Crack et al.77 |