TABLE 1.

Subject characteristics

	RMW	Controls	p-value#	p-value¶
Age years	29±3	29±2	0.68
Sex male: female	11:1	11:1
Height cm	163±6	174±2	0.17
Weight kg	59.5±8.2	71.4±1.9	0.26
FVC L (% pred)	1.14±0.24 (23.9±4.1)	5.10±0.21 (99.5±3.0)	<10−11	<10−12
FEV1 L (% pred)	1.03±0.19 (27.8±4.6)	4.10±0.18 (102.4±4.8)	<10−10	<10−9
TLC L (% pred)	2.72±0.48 (44.6±5.9)	6.77±0.24 (97.1±2.4)	<10−7	<10−7
VC L (% pred)	1.17±0.23 (24.03±4.0)	5.24±0.18 (102.8±3.5)	<10−11	<10−11
IC L (% pred)	0.96±0.21 (29.1±4.8)	3.43±0.17 (95.9±4.9)	<10−8	<10−8
FRC L (% pred)	1.77±0.29 (62.2±7.8)	3.30±0.19 (97.3±4.3)	<10−11	<10−3
ERV L (% pred)	0.22±0.06 (12.5±2.6)	1.78±0.10 (103.2±5.6)	<10−11	<10−10
RV L (% pred)	1.55±0.27 (118.1±16.4)	1.52±0.12 (91.5±5.1)	0.92	0.32
MIP cmH2O (% pred)	29.6±6.02 (28.5±7.7)	132.89±7.17 (126.3±6.7)	<10−9	<10−8
MEP cmH2O (% pred)	29.5±6.69 (21.4±5.3)	165.58±11.34 (116.3±7.4)	<10−9	<10−9
PEF L·s−1 (% pred)	2.67±0.38 (32.9±4.2)	10.20±0.56 (113.0±5.6)	<10−6
PCF L·s−1	2.49±0.39	10.07±0.50	<10−8
VT L	0.41±0.03	0.96±0.06	<10−7
fR bpm	27±2	14±1.7	<10−4
V′E L·min−1	10.6±0.6	12.6±1.3	0.19
Heart rate beats·min−1	83±6	73±5	0.34
Pa mmHg	87±6	80±4	0.36

Data are presented as mean±sem (% predicted), unless otherwise stated. RMW: respiratory muscle weakness; FVC: forced vital capacity; FEV₁: forced expiratory volume in 1 s; TLC: total lung capacity; VC: vital capacity; IC: inspiratory capacity; FRC: functional residual capacity; ERV: expiratory reserve volume; RV: residual volume; MIP: maximum inspiratory pressure; MEP: maximum expiratory pressure; PEF: peak expiratory flow; PCF: peak cough flow; V_T: tidal volume; f_R: respiratory frequency; V′_E: minute ventilation; P_a: mean arterial pressure. ^#: p-values for comparisons of absolute measures of subject characteristics in the RMW group versus controls. ^¶: p-values for comparisons of % pred measures of lung function parameters in the RMW group versus controls.