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Role of human AKRs in health and disease.
| AKR | Associated disease | Selective inhibitors | Clinical trial phase |
|---|---|---|---|
| AKR1C1 | Colorectal cancer Breast cancer Endometrial cancer Pre-term birth NCSCL | 3-Bromo-5-phenyl salicylic acid | Preclinical |
| AKR1C2 | Androgen insufficiency | Ursodedeoxycholate | Preclinical |
| AKR1C3 | HPRC Breast cancer Acute myeloid leukemia NSCLC | Indomethacin 6-medroxyprogesterone acetate | Clinically |
| AKR1C4 | Paranoia | Preclinical |
