FIG. 2.

Aβ binding targets and candidate associated neurodegenerative mechanisms. Extracellular Aβ interacts with a number of neuronal and glial cell surface receptors. Evidence suggests that many of these interactions promote stress kinase and other signaling triggering neurodegenerative processes. Intracellular Aβ is also likely to bind to one or more targets to contribute to neurodegenerative signaling.