Figure 3. FIGURE 3: Cyclin C regulation of mitochondrial morphology and PCD following ROS stress.

Upon release from the mediator complex, cyclin C enters the cytoplasm where it associates with Mdv1 promoting Mdv1-Dnm1 complex formation and extensive mitochondrial fragmentation. Thereafter, cyclin C disassociates from the fission complex and is destroyed by ubiquitin-mediated degradation. An additional stress signal, in combination with hyper-fission and Ybh3 localization to the mitochondria, is needed to complete the PCD pathway (represented by MOMP and cytochrome c release).