TABLE 3.

Change in Total UPDRS after Second Randomization to Either Selegiline or Placebo While Taking Levodopa

Duration after Randomization	Placebo	Selegiline	Difference
1 month	0.50 ± 7.73	−1.52 ± 7.54	2.02
3 months	1.57 ± 9.41	−0.85 ± 9.42	2.42
9 months	4.18 ± 10.12	1.63 ± 10.61	2.55
15 months	5.63 ± 10.73	0.46 ± 10.88	5.17
21 months	7.06 ± 12.70	1.51 ± 10.36	5.55
			p = 0.0002
Increase of l-dopa mg/day	181 ± 246	106 ± 205	p = 0.003

From Shoulson et al.¹²³ Higher UPDRS represents more severe PD.