Table 3.
Dose-dependent assay for anticancer evaluation.
Compound No. | Na | LogGI50 | Log TGI | Log LC50 | ||||||
---|---|---|---|---|---|---|---|---|---|---|
N1b | Range | MG_MID | N2b | Range | MG_MID | N3b | Range | MG_MID | ||
BT1 | 3 | 3 | −4.64 to −6.49 | −5.07 | 56 | −4.0 to −4.83 | −4.4 | 19 | −4.0 to −4.36 | −4.06 |
BT4 | 3 | 3 | −4.64 to −6.52 | −5.33 | 37 | −4.0 to 5.08 | −4.36 | 09 | −4.0 to −4.28 | −4.02 |
BT8 | 3 | 3 | −4.0 to −4.84 | −4.45 | 08 | −4.0 to −4.24 | −4.02 | 00 | −4.0 to −4.02 | −4.0 |
BT17 | 3 | 3 | −4.42 to −5.02 | −4.71 | 25 | −4.0 to −4.32 | −4.07 | 03 | −4.0 to −4.08 | −4.0 |
BT18 | 3 | 3 | −3.92 to −6.93 | −4.90 | 49 | −3.92 to −6.01 | −4.07 | 49 | −3.92 to −4.75 | −4.29 |
N – no. of human cancer cell lines tested at the IInd stage assay;
N1, N2, N3 – no. of sensitive cell lines, against which the compound possessed considerable growth inhibition as per the standard parameter (logGI50, logTGI, and log LC50 ≥4.00) (GI50 (50% of net cell growth inhibition at molar concentration of the compound.) TGI (Total inhibition at molar concentration of the compound) and LC50 (50% of net cell death at molar concentration of the compound).