. 2004 Apr;1(2):196–205. doi: 10.1602/neurorx.1.2.196

TABLE 1.

Summary of the Literature on Serial MR-Based Volume Measurements in AD

Source	Region	N (control/AD)	Change in Controls (mean ± SD per year)	Change in AD (mean ± SD per year)	Difference per year
Kaye et al.⁷⁹	Hippocampi	18/12 (preclinical AD)	−2.09%	−2.33%	−0.14%
	Parahippocampal gyri		−2.16%	−2.92%	−0.76%
	Temporal lobes		0%	−1.27%	−1.27%^*
	Whole brain volume		0.27%	0.08%	0.19%
Jack et al.⁸⁴	Hippocampi	24/24	−1.55% ± 1.38%	−3.98% ± 1.92%	−2.43%^*
	Temporal horns		6.15% ± 7.69%	14.16% ± 8.47%	8.01%^*
Fox et al.⁸⁹	Whole brain volume	18/18	−0.41% ± 0.47%	−2.37% ± 1.11%	−1.96%^*
Laakso et al.⁸⁵ ^†	Right hippocampus	8/27	−1.6% ± 15.1%	−6.9% ± 18.2%	−5.3%
	Left hippocampus		−3.6% ± 15.1%	−7.2% ± 20.1%	−3.6%
Teipel et al.⁸⁷	Corpus callosum (total)	10/21	−0.9% ± 5.0%	−7.7% ± 6.7%	−6.8%^*
	C1 (rostrum and genu)		1.6% ± 6.3%	−12.1% ± 15.1%	−13.7%^*
	C2 (anterior truncus)		3.9% ± 12.1%	−10.3% ± 18.8%	−14.2%^*
	C3 (middle truncus)		−1.6% ± 9.5%	−3.0% ± 10.6%	−1.4%
	C4 (posterior truncus)		−3.7% ± 12.7%	4.0% ± 18.1%	7.7%
	C5 (splenium)		0.7% ± 3.6%	−7.3% ± 9.3%	−8%^*
Bradley et al.⁹⁷	Brain volume	32/5	−0.2% ± 0.23%	−2.14% ± 0.52%	−1.94%^*
	Ventricle volume		4.1% ± 0.9%	13.0% ± 2.4%	8.9%^*
	Ventricle/brain ratio		−4.3% ± 1.1%	−15.6% ± 2.8%	−11.3%^*
Wang et al.⁹¹	Cerebrum	14/14	−0.4% ± 0.5%	−2.4% ± 1.2%	−2%^*
	Lateral ventricles		1.9% ± 4.2%	13.8% ± 4.8%	11.9%^*
	Temporal lobes		−0.7% ± 0.5%	−3.4% ± 2.0%	−2.7%^*
Silbert et al.⁸¹	CNS volume	24/15	−1.8 cc ± 9.6 cc	−17.9 cc ± 18.0 cc	−16.1 cc
	Ventricle volume		3.3 cc ± 3.5 cc	5.5 cc ± 3.2 cc	2.2 cc

There is a statistically significant difference between the rate of change in controls and patients with AD.

^†

Change in 3 years.