TABLE 2.
Performance of CSF Total Tau as a Biomarker for Alzheimer’s Disease
Study Number | Number of AD Cases | AD Sensitivity | Number of Controls | Controls Specificity | Comment | Ref. |
---|---|---|---|---|---|---|
1 | 70 | 100 | 19 | 100 | 62 | |
2 | 44 | 84 | 31 | 97 | 14 | |
3 | 43 | 95 | 18 | 94 | Community-based study | 63 |
4 | 69 | 89 | 17 | 100 | 64 | |
5 | 93 | 40 | 41 | 100 | Multicenter study | 56 |
6 | 40 | 89 | 36 | 97 | 65 | |
7 | 163 | 66 | 65 | 83 | Multicenter study | 66 |
8 | 150 | 79 | 100 | 70 | Multicenter study | 67 |
9 | 81 | 90 | 15 | 67 | 41 | |
10 | 407 | 93 | 93 | 86 | Community-based study | 20 |
11 | 60 | 79 | 32 | 82 | 50 | |
12 | 54 | 87 | 15 | 93 | 68 | |
13 | 47 | 77 | 12 | 92 | 69 | |
14 | 41 | 85 | 17 | 95 | 70 | |
15 | 80 | 81.3 | 21 | 91 | 71 | |
16 | 52 | 79 | 56 | 100 | 24 | |
17 | 74 | 95 | 40 | 98 | 72 | |
18 | 366 | 59 | 316 | 97 | Multicenter study | 73 |
19 | 49 | 88 | 49 | 96 | 3-year follow-up | 74 |
20 | 39 | 72 | 12 | 93 | 75 | |
Total | 2022 | 81.4 | 1005 | 91.5 |
Ref. = reference number.