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. Author manuscript; available in PMC: 2017 Mar 14.
Published in final edited form as: Neuroscience. 2016 Dec 5;343:77–84. doi: 10.1016/j.neuroscience.2016.11.037

Fig. 5.

Fig. 5

NLRP3 inflammasome inhibitor Ac-YVAD-CMK decreases microglial activation. (A) Fluorescent image shows Iba1-positive cells in the hippocampus. (B) Quantification analysis showed that LPS mice had significantly more Iba1-positive microglia in the hippocampus than did the control and YVAD groups. The number of activated, Iba1-positive microglia was significantly less in the Ac-YVAD-CMK-treated LPS mice than in the LPS-only mice (n = 6 mice/group, **p < 0.01 vs. control and YVAD groups, ##p < 0.01 vs. LPS group). Data are presented as mean ± SD. Scale bar = 40 μm.