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WHO classification of neuroendocrine tumors of the lung (2015) [Travis et al. 2015].
| Differentiation | Grade | Mitotic rate | Diagnosis |
|---|---|---|---|
| Well differentiated | Low grade | <2 mitoses per 2 mm2 AND no necrosis | TC tumor |
| Intermediate grade | 2–10 mitoses per 2 mm2 or foci of necrosis | AC tumor | |
| Poorly differentiated | High grade | ⩾11 mitoses per 2 mm2 | SCLC LCNEC |
TC, typical carcinoid; AC, atypical carcinoid; SCLC, small cell lung cancer; LCNEC, large cell neuroendocrine cancer.
