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. 2017 Mar 14;7:44229. doi: 10.1038/srep44229

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Hydrolysis rates for cholesterol prodrug nanoparticles (a) and TML prodrug nanoparticles (b). Cholesterol prodrug nanoparticles were not hydrolysed by enzymes present in the aqueous humour, whereas TML prodrug nanoparticles immediately released brinzolamide.