Table 6. Investigation of the risk factors of early mortality using univariate and multivariate Cox regression analysis.
| Variables | Univariate analysis |
Multivariate analysis* |
||
|---|---|---|---|---|
| HR 95% CI | P-value | HR 95% CI | P-value | |
| Very old age (≥81 years) | 3.16 (1.59–6.23) | 0.001 | 4.69 (1.79–12.27) | 0.002 |
| Male gender | 1.23 (0.63–2.42) | 0.541 | ||
| Performance status 2–4 | 3.21 (1.64–6.31) | 0.001 | 1.06 (0.47–2.40) | 0.880 |
| aaIPI 2 or 3 | 13.15 (3.15–54.93) | <0.001 | 7.43 (1.08–51.09) | 0.041 |
| BM involvement | 2.58 (1.26–5.29) | 0.010 | 2.74 (1.13–6.61) | 0.025 |
| Stage 3 or 4 | 4.97 (1.75–14.12) | 0.003 | 0.69 (0.17–2.79) | 0.602 |
| Abnormal LDH level | 7.59 (1.82–31.72) | 0.005 | 1.49 (0.29–7.62) | 0.635 |
| Abnormal B2M level | 2.64 (1.30–5.33) | 0.007 | 1.05 (0.45–2.42) | 0.915 |
| Low albumin level | 3.17 (1.48–6.80) | 0.003 | 1.38 (0.58–3.83) | 0.464 |
| Renal function impairment | 2.40 (1.22–4.71) | 0.011 | 1.00 (0.42–2.36) | 0.998 |
| Presence with B symptom | 2.56 (1.31–5.03) | 0.006 | 1.67 (0.76–3.67) | 0.204 |
| Symptoms of TLS at diagnosis | 4.26 (1.75–10.36) | 0.001 | 2.96 (0.86–10.19) | 0.086 |
| At least 1 comorbidity | 2.24 (0.87–5.78) | 0.096 | 1.63 (0.59–4.47) | 0.342 |
| CCI ≥ 1 | 1.29 (0.66–2.55) | 0.448 | ||
*Factors with P-value less than 0.1 in the univariate analysis were entered into the multivariate logistic regression model. aaIPI, age-adjusted international prognostic index; B2M, beta2-microglobulin; CCI, Charlson comorbidity index; HR, hazard ratio; LDH, lactate dehydrogenase; TLS, tumour lysis syndrome.