Fig 3. Deletion of Ttc21b with EIIa-Cre phenocopies homozygous Ttc21b^aln/aln embryos.

Genetic ablation of Ttc21b with the EIIa-Cre creates microcephalic brains (D,G) which are similar to that seen in homozygous null embryos (L,M). The ROSA^dTom/EGFP reporter allele shows the mosaic nature of some EIIa-Cre embryos where EGFP expression (B,E,H) marks recombined tissue and dTom expression (C,F,I) indicates tissue without Cre activity. All paired images are at the same magnification. (t = telencephalon)