Table 1.

Clinical parameters of ALS patients.

Clinical measure/ALS subgroups	ALS-CST + mean ± SD	ALS-CST − mean ± SD	p
n	21	24	NS
Age (years)	52.3 ± 11.4	59.5 ± 12.1	< 0.05
Symptom duration prior to MRI (months)	9.6 ± 5.5	36.4 ± 44.2	< 0.001
ALSFRS-R score	34.6 ± 7.8	34.1 ± 8.1	NS
Disease progression rate	1.38 ± 1.64	0.46 ± 0.43	0.001

Key:

SD - Standard deviation.

ALS-CST + - ALS patients with predominant upper motor neuron (UMN) signs and hyperintense signal along the corticospinal tract (CST) on conventional proton density (PD) and T2-weighted images and no clinical dementia.

ALS-CST − - ALS patients with predominant UMN signs without CST hyperintensity and no clinical dementia (ALS-CST −).

ALSFRS-R - ALS functional rating score-revised.

NS - Not significant.