Fig 2.

a and b. Long-term effects of adolescent EtOH binge drinking after cocaine withdrawal in adulthood on prepulse inhibition (PND 81–82). During adolescence mice (n = 10 per group) were pretreated for 14 days (PND 34–47) with Sal or EtOH (1.25 g/kg administered 16 times in two daily i.p. injections separated by a 4-h interval on two consecutive days followed by a 48-h “drug-free” period), and in adulthood with Sal or Coca by three daily i.p. injections separated by a 60-min interval according to the following regime: 5 mg/kg on PND 68 and 69, 15 mg/kg from PND 70 to 72, a 2-day abstinence period, and 25 mg/kg from PND 75 to 79. Animals were tested on PND 82. Bars depict mean ± SEM of percentage of the PPI response for trials with prepulses of 75 dB (panel a) and 85 dB (panel b) for all groups (** and * p<0.01 and 0.05 respectively, significantly different from the rest).