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. 2017 Mar 14;12(3):e0172956. doi: 10.1371/journal.pone.0172956

Fig 4. Long-term effects of adolescent EtOH binge drinking after cocaine withdrawal in adulthood on object recognition (PND 83–84).

Fig 4

During adolescence mice (n = 10 per group) were pretreated for 14 days (PND 34–47) with Sal or EtOH (1.25 g/kg administered 16 times in two daily i.p. injections separated by a 4-h interval on two consecutive days followed by a 48-h “drug-free” period), and on adulthood with Sal or Coca by three daily i.p. injections separated by a 60-min interval according to the following regime: 5 mg/kg on PND 68 and 69, 15 mg/kg from PND 70 to 72, a 2-day abstinence period, and 25 mg/kg from PND 75 to 79. Animals were tested on PND 84. Bars depict mean ± SEM of the DI for all groups (** p<0.01 significantly different from the Sal-Sal group; ## p<0.01 significantly different from the rest).