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. 2017 Mar 14;12(3):e0172956. doi: 10.1371/journal.pone.0172956

Fig 9. Long-term effects of previous EtOH binge drinking after later cocaine withdrawal in adulthood on object recognition (PND 118).

Fig 9

Over PND 68–81 mice (n = 10 per group) were pretreated with Sal or EtOH (1.25 g/kg administered 16 times in two daily i.p. injections separated by a 4-h interval on two consecutive days followed by a 48-h “drug-free” period). Twenty-one days later, animals were treated with Sal or Coca in three daily i.p. injections separated by a 60-min interval according to the following regime: 5 mg/kg on PND 102 and 103, 15 mg/kg from PND 104 to 106, a 2-day abstinence period, and 25 mg/kg from PND 109 to 113. Animals were tested on PND 118. Bars depict mean ± SEM of the DI for all groups (** p<0.01 significantly different from the Sal-Sal group).