Table 4.
LS mean change from baseline to last visit in ACQ score of between-treatment differences with Cic 640, 320 and 160 μg/day by exacerbation history subgroups (ITT)
| Variable | Cic 160 μg/day (N=120); n (%) |
Cic 320 μg/day (N=122); n (%) |
Cic 640 μg/day (N=125); n (%) |
Change in ACQ score Cic 640 μg/day vs Cic 160 μg/day; Cic 320 μg/day vs Cic 160 μg/day |
||
|---|---|---|---|---|---|---|
| LS mean (SE) | 95% CI | Two-sided P-value | ||||
| Exacerbation history* | ||||||
| ≥1 | 21 (17.5) | 22 (18.0) | 25 (20.0) | −0.586 (0.2663); 0.468 (0.2751) | −1.110, −0.062; −0.073, 1.009 | 0.0285; 0.0898 |
| 0 | 70 (58.3) | 70 (57.4) | 63 (50.4) | 0.019 (0.1540); −0.108 (0.1505) | −0.284, 0.322; −0.404, 0.188 | 0.9035; 0.4734 |
| Unknown | 29 (24.2) | 30 (24.6) | 37 (29.6) | −0.101 (0.2216); 0.034 (0.2332) | −0.537, 0.335; −0.425, 0.492 | 0.6494; 0.8855 |
Notes:
*
Post hoc subgroup analysis. Exacerbation history subgroups categorized according to the number of exacerbations in the previous year. LS mean values are from ANCOVA.
Abbreviations: ACQ, Asthma Control Questionnaire; ANCOVA, analysis of covariance; Cic, ciclesonide; CI, confidence interval; ITT, intention-to-treat; LS, least squares; SE, standard error.