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. Author manuscript; available in PMC: 2017 Mar 14.
Published in final edited form as: Curr Pharm Biotechnol. 2012 Jun;13(7):1346–1359. doi: 10.2174/138920112800624409

Figure 6.

Figure 6

Model geometry for the paracellular pathway of the BBB (Not in scale). The thickness of the endothelial surface glycocalyx layer is Lf. The inter-endothelial cleft has a length of L and a width of 2B. The length of the tight junction strand in the inter-endothelial cleft is Ljun. The width of the small continuous slit in the junction strand is 2Bs. The distance between the junction strand and luminal front of the cleft is L1. The width of the basement membrane is 2Lb and the length of the astrocyte foot processes is 2Wa. The cleft between astrocyte foot processes has a length of La and a width of 2Ba. The surface glycocalyx layer and the endothelial cells are defined as the Endothelium only while the BBB is defined to include the endothelium, the basement membrane and the astrocytes. Redrawn from [40].