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. Author manuscript; available in PMC: 2017 Mar 14.
Published in final edited form as: ACS Chem Neurosci. 2015 Aug 11;6(10):1726–1731. doi: 10.1021/acschemneuro.5b00160

Figure 1.

Figure 1

Inhibition of [3H]dopamine uptake by α-PVP analogs. The upper panel depicts effects of altering α-carbon chain length (8, 11, 12), whereas the lower panel depicts effects of ring expansion (15, 16) or conformational constraint (17). Data are mean ± SD for n = 3 experiments performed in triplicate. Uptake inhibition curves were generated by incubating rat caudate synaptosomes with compounds diluted in assay buffer as described in Methods.