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. Author manuscript; available in PMC: 2017 Mar 14.
Published in final edited form as: ACS Chem Neurosci. 2015 Aug 11;6(10):1726–1731. doi: 10.1021/acschemneuro.5b00160

Figure 2.

Figure 2

Relationship between pIC50 for inhibition of DAT versus substituent volume in Å3 (upper panel; r = 0.909, p = 0.0017) and lipophilicity (π) (lower panel; r = 0.917, p = 0.0013) for compounds 7–14.