Table 1.

Potency of α-PVP (7) Analogs as Inhibitors at DAT^a

	R	IC50, nM (SD)
8	–H	3250(±418)
9	–CH3	196.7b
10	–CH2 CH3	63.3b
7	–CH2CH2CH3	17.5 (±1.7)
11	–CH(CH3)2	92.3 (±11.6)
12	–CH2(CH2)2CH3	11.6 (±0.6)
13	–C5H9	17.1 (±2.5)
14	–C6H11	8.3 (±1.1)
15	–CH3	2490(±241)
16	–CH2CH2CH3	128(±13)
17		12900(±1890)

^aCompounds had no activity at SERT at 10000 nM.

^bData reported earlier.¹⁵