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. 2017 Mar 15;28(6):760–770. doi: 10.1091/mbc.E16-07-0498

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© 2017 Chechenova et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 5: — TpnC is required for myofibril assembly. Confocal images of cryosectioned IFM and TDT muscles from WT and TpnC41C^∂#2 TpnC4^∂#25 double-knockout mutants stained for F-actin, Sallimus (Sls), and Obscurin. (A-A″, B–B″, C–C″, D–D″) Staining with phalloidin (green) and anti-Sls antibody (magenta). (A-A″, B–B″) IFM. (C–C″, D–D″) TDT myofibrils. (E–E″, F–F″, G–G″, H–H″) Immunostaining with phalloidin (green) and anti-Obscurin antibody (magenta). (E–E″, F–F″) IFM. (G–G″, H–H″) Images of TDT. Scale bar, 5 μm. All images represent longitudinal sections of the muscles. Note that myofibril organization is disrupted in the mutants compared with controls.