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. 2016 Dec 23;31(4):1354–1367. doi: 10.1096/fj.201601134R

Figure 2.

Figure 2.

PGRN increased Treg cells in CIA independent of IL-10. A) FACS analysis of Treg cells, CD4+IL17+ and CD4+IFN-γ+ T cells, and IL-10–producing CD4+ T cells and Treg cells in the spleens and lymph nodes (LNs) of CIA mice treated with or without PGRN (n = 12 per group). Bar graphs represent means ± sd of total mice per group. B) ELISA analysis of sera levels of IL-10, IL-17, IL-6, and TNF-α in CIA mice treated with or without with PGRN for 5 wk. KO, knockout; ND, nondetectable. Values are means ± sd. *P < 0.05; **P < 0.01 vs. PBS-treated control group.