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. 2017 Jan 9;31(4):1547–1555. doi: 10.1096/fj.201600735R

Figure 1.

Figure 1.

Effects of LPA and VPC31143 on the tone of endothelium-denuded murine TA or AA segments. A) Representative recordings of vessels prepared from WT mice. “W” denotes wash-out with Krebs solution. B) AA segments showed 2-fold higher contraction compared with TA segments when stimulated with VPC31143. VPC31143 stimulation elicited more than twice as forceful contractions in the AA compared with LPA. ****P < 0.0001 vs. VPC effect in the TA; ####P < 0.0001 vs. LPA effect in the AA; 2-way ANOVA with Tukey’s post hoc test (n = 18–32 vessels obtained from 14–32 animals).