Skip to main content
. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: J Orthop Res. 2016 Mar 21;34(11):1941–1949. doi: 10.1002/jor.23204

Figure 2.

Figure 2

Progressive cartilage degeneration occurred following a single loading session in adult mice without creating immediate physical damage (A and B). Superficial zone collagen loss was not altered by the single loading session (C). Loading also thinned articular cartilage (Ca.Th) at the lateral posterior quadrant (D). Chondrocyte apoptosis, measured by immunohistochemical staining for caspase-3 positive chondrocytes in articular cartilage was not altered by the single loading session (E). Control images represent a non-loaded contralateral limb at each time point. Scale bar = 100 μm. Data presented as mean ± SD of 7/group. ^Loading, †time, §loading*time, p < 0.05 by repeated measures two-way ANOVA. Groups with different letters are significantly different by post-hoc comparisons of means with Bonferroni correction.