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. 2016 Nov 30;7(52):85697–85708. doi: 10.18632/oncotarget.13730

Figure 5. Rg3 inhibits PrP (106-126)-induced mitochondrial dysfunction in neuronal cells.

Figure 5

(A) Primary neurons were treated with 6.25, 12.5, or 25 μM of Rg3 for 6 h followed by incubation with PrP (106-126) for 12 h. Treated cells were used to measure JC-1 mono form (green) by flow-cytometry. R2 represents the population of JC-1 monomeric cells. (B) Bar graph indicating the averages of green fluorescent cells. (C) Representative images of J aggregate formation in SK-N-SH cells as described in A. *p < 0.05, *** p < 0.001: significant differences between the control and each treatment group.