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. 2016 Dec 9;7(52):85728–85740. doi: 10.18632/oncotarget.13828

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Copyright: © 2016 Yang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

Experimental-supported miRNA-lncRNA and miRNAs-mRNA interactions were downloaded from starBase and miRTarBase. miRNA-lncRNA and miRNA-mRNA pairs sharing the same miRNA form the global crosstalk network. If the Pearson correlation coefficient between competing lncRNA-mRNA pairs > 0 and q value < 0.05 in ESCC tumor or adjacent tissues, the competing lncRNA-mRNA pairs were retained and formed the active crosstalk network. Finally, subtype-specific differential mRNA-lncRNA crosstalk networks based on ceRNA hypothesis are respectively constructed by integrating DEGs and DCLs.