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. 2015 Oct 26;7(52):85750–85763. doi: 10.18632/oncotarget.5509

Figure 5. GMF-β knockdown suppresses tumor growth and the formation of human-CD31 positive microvessels (hCD31-MVs) in orthotopic U87 xenograft models.

Figure 5

A. The cross-sectional appearance of xenografted gliomas from U87-mock group B. The cross-sectional appearance of xenografted gliomas from U87-shGMF-β group. Gross tumor boundaries were delineated by white dotlines. C. A hCD31-microvessel and several hCD31-negative vessels in U87-mock tumor. D. No hCD31-MVs, only hCD31-negative vessels in U87-shGMF-β tumor. Red solid arrows indicate hGMF-β staining in tumor cells, black solid arrows show hCD31 staining on microvasular endothelia, and open arrows denote vessels negative for hCD31. Scale bar: 100 μm in upper pannels; 50 μm in lower pannels. E. Quantitative comparisons of gross tumor volume between U87-mock and U87-shGMF-β group. F. Quantitative comparisons of hCD31-microvessel densities (MVDs) between U87-mock and U87-shGMF-β group.