Table 2. Low Ki67/high ATM expression independently predicts favorable disease survival in a multivariate model in low Ki67 subgroup of ES-HPBC (Stage I-III).
| Variables | pvalue | HR (95%CI) |
|---|---|---|
| Low Ki67/high ATM vs Low Ki67/low ATM | 0.02 | 0.36 (0.15-0.88) |
| Tumor size (T1/2 vs T3/4) | 0.01 | 0.16 (0.04-0.69) |
| LN status (- vs +) | 0.14 | 0.49 (0.20-1.25) |
| LVI (_- vs +) | 0.16 | 0.51 (0.20-1.31) |
| Grade (1/2 vs 3) | <0.0001 | 0.28 (0.11-0.67) |
| Age (<65 vs >65) | 0.01 | 0.26 (0.10-0.74) |
Stage I-III patients with low Ki67 expression were selected for this analysis. A multivariable model was created using selected known prognostic factors such as tumor size, lymph node (LN) status, lymphovascular invasion (LVI), grade and age. Cox proportional hazards regression methods were used to calculate p values, hazard ratio (HR) and confidence interval (CI) of each variable in the model.