Table 2. Polymorphisms associated with GIS in FD patients.
| Genotype number (%) | |||||||
|---|---|---|---|---|---|---|---|
| dsSNP ID* | Gene | Chr | Alleles | Patients with GIS (N=12) | Patients without GIS (N = 37) | P-value | OR (95% C.I.) |
| GG = 4 (33.0) | GG =20 (54.0) | ||||||
| rs2501870 | NR1I3 | 1 | A/G | AG = 8 (67.0) | AG = 10 (27.0) | 0,0191 | 5.4 (1.33 to 21.95) |
| AA = 0 (0.00) | AA = 7 (19.0) | ||||||
| TT = 1 (8.00) | TT=11 (30.0) | ||||||
| rs7636910 | ABCC5 | 3 | C/T | CT =11 (92.0) | CT = 16 (43.0) | 0,0060 | 14.44 (1.69 to 123.69) |
| CC = 0 (0.00) | CC = 10 (27.0) | ||||||
| TT =1 (8.00) | TT = 13 (35.0) | ||||||
| rs497692 | ABCB11 | 2 | C/T | CT = 10 (84.0) | CT = 14 (38.0) | 0,0083 | 8.21 (1.57 to 43.08) |
| CC = 1 (8.00) | CC = 10 (27.0) | ||||||
| TT = 1 (8.00) | TT = 10 (27.0) | ||||||
| rs495714 | ABCB11 | 2 | C/T | CT = 11 (92.0) | CT = 14 (38.0) | 0,0019 | 18.07 (2.10 to 155.49) |
| CC = 0 (0.00) | CC = 13 (35.0) | 0,0215 | 0.073 (0.004 to 1.32) | ||||
| TT = 1 (8.00) | TT = 12 (32.0) | ||||||
| rs496550 | ABCB11 | 2 | C/T | CT =10 (84.0) | CT = 14 (38.0) | 0,0083 | 8.21 (1.57 to 43.08) |
| CC =1 (8.00) | CC = 11 (30.0) | ||||||
| TT = 1 (8.00) | TT = 11 (30.0) | ||||||
| rs473351 | ABCB11 | 2 | C/T | CT =10 (82.0) | CT = 14 (38.0) | 0,0083 | 8.21 (1.57 to 43.08) |
| CC = 1 (8.00) | CC = 12 (32.0) | ||||||
| CC =1(8.00) | CC =16 (43.0) | 0,0371 | 0.12 (0.01 to 1.02) | ||||
| rs2291075 | SLCO1B1 | 12 | C/T | CT = 10 (84.0) | CT = 13 (35.0) | 0,0065 | 9.23 (1.75 to 48.62) |
| TT= 1 (8.00) | TT = 8 (22.0) | ||||||
| CC = 4 (34.0) | CC = 26 (70.0) | 0,0392 | 0.21 (0.05 to 0.85) | ||||
| rs11045819 | SLCO1B1 | 12 | A/C | AC = 7 (58.0) | AC = 8 (22.0) | 0,0289 | 5.08 (1.26 to 20.36) |
| AA = 1 (8.00) | AA = 3 (8.00) | ||||||
| AA = 1 (8.00) | AA = 13 (35.0) | ||||||
| rs2306283 | SLCO1B1 | 12 | A/G | AG = 10 (84.0) | AG = 14 (38.0) | 0,0083 | 8.21 (1.57 to 43.08) |
| GG = 1 (8.00) | GG = 10 (27.0) | ||||||