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. 2016 Nov 15;7(52):86134–86147. doi: 10.18632/oncotarget.13348

Figure 8. Integration of Gli1-Foxm1 axis and EGFR-PI3K/AKT signaling enhance colorectal metastasis.

Figure 8

(A) The invasive capacity of LOVO cells treated with EGF and EGF combined with different drugs was determined using invasion assays. (B) The invasive capacity of LOVO cells treated with N-shh and N-shh combined with different drugs was determined using invasion assays. (C, D) Comparative analysis of relative invation ration in Lovo cells treated with different drugs in Transwell assays. (E) p-AKT, Gli1, Foxm1 expresson levels analysed by qRT-PCR in LOVO cells treated with EGF or not. (F) p-AKT, Gli1, Foxm1 expresson levels analysed by qRT-PCR in LOVO cells treated with N-shh or not. (G, H) Comparative analysis of protein levels in Lovo cells treated with different drugs.