Table 1. Clinico-pathological association of 18q deletion in all cancers, ERG-negative cancers and ERG-positive cancers.
All cancers | ERG-negative cancers | ERG-positive cancers | |||||||
---|---|---|---|---|---|---|---|---|---|
n | 18q deletion (%) | p value | n | 18q deletion (%) | p value | n | 18q deletion (%) | p value | |
All cancers | 6881 | 7.5 | 3419 | 8.2 | 2977 | 6.4 | |||
Tumor stage | |||||||||
pT2 | 4360 | 6.4 | < 0.0001 | 2260 | 6.9 | 0.0004 | 1751 | 5.1 | < 0.0001 |
pT3a | 1559 | 8.0 | 687 | 9.8 | 790 | 6.5 | |||
≥ pT3b | 930 | 11.8 | 459 | 12.0 | 418 | 11.2 | |||
Gleason grade | |||||||||
≤ 3+3 | 1636 | 6.9 | 0.0013 | 799 | 7.9 | 0.1842 | 667 | 5.0 | 0.0011 |
3+4 | 3804 | 6.8 | 1826 | 7.5 | 1745 | 5.6 | |||
4+3 | 1058 | 10.1 | 569 | 10.2 | 428 | 10.3 | |||
≥ 4+4 | 344 | 9.9 | 208 | 9.6 | 116 | 10.3 | |||
PSA Level (ng/μl) | |||||||||
< 4 | 863 | 8.0 | 0.0630 | 377 | 7.4 | 0.3525 | 413 | 8.2 | 0.0698 |
4–10 | 4035 | 6.7 | 1961 | 7.7 | 1784 | 5.5 | |||
10–20 | 1383 | 8.8 | 756 | 9.7 | 539 | 6.7 | |||
> 20 | 510 | 8.4 | 289 | 7.3 | 195 | 9.2 | |||
Lymph node metastasis | |||||||||
N0 | 3905 | 7.4 | 0.2688 | 1973 | 7.7 | 0.1854 | 1690 | 6.9 | 0.8311 |
N+ | 400 | 9.0 | 191 | 10.5 | 186 | 6.5 | |||
Surgical margin | |||||||||
negative | 5390 | 7.2 | 0.0416 | 2694 | 8.0 | 0.3797 | 2300 | 5.9 | 0.0581 |
positive | 1366 | 8.9 | 664 | 9.0 | 620 | 8.1 |