Figure 2. A. Five of the top 10 miRNAs have experimentally validated gene targets.

Gene targets involved in cancer are shown. Pink molecules are important in breast cancer pathway. The connections show experimentally validated targets (solid line) and targets predicted with high confidence (dash line). B. The top network of the validated gene targets is enriched in cell death and survival, cancer, liver necrosis/cell death (P =10^-50, right-tailed Fisher's exact test). Fill colors represent molecules directly targeted by the corresponding miRNAs.